Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug
نویسندگان
چکیده
منابع مشابه
Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug
In the present investigation, mixed-solvency approach has been applied for the enhancement of aqueous solubility of a poorly water- soluble drug, zaltoprofen (selected as a model drug), by making blends (keeping total concentrations 40% w/v, constant) of selected water-soluble substances from among the hydrotropes (urea, sodium benzoate, sodium citrate, nicotinamide); water-soluble solids (PEG-...
متن کاملSolubilization of Poorly Water Soluble Drug Using Mixed Solvency Approach for Aqueous Injection
Aim: 1) To increase water solubility of indomethacin drug using mixed solvency approach. 2) To employ use of non toxic solubilizers for increasing solubility of a poorly water soluble drug. Study Design: Trial and error based experimental study. Place and Duration of Study: School of Pharmacy, Devi Ahilya Vishwavidyalaya, UTD, Takshashila Campus, Indore, India and College of Pharmacy, IPS Acade...
متن کاملFormulation development and evaluation of diclofenac sodium injection using benzyl alcohol (co-solvent), mixed solvency concept
Introduction: Mixed solvency is a concept of solubilization of the material. For producing new formulation, especially in the form of injection it is essential to solubilize the active pharmaceutical ingredients (API) in the solvent and that must be stable throughout the shelf life. Aqueous solubility of raw materials is important for injection formulation, but in some cases if the drug is not ...
متن کاملreflections on taught courses of the iranian ma program in english translation: a mixed-methods study
the issue of curriculum and syllabus evaluation and revision has been in center of attention right from when curriculum came into attention of educational institutions. thus everywhere in the world in educational institutions curricula and syllabi are evaluated and revised based on the goals, the needs, existing content, etc.. in iran any curriculum is designed in a committee of specialists and...
Enhancement of Solubility of Poorly Water Soluble Drugs Diclofenac Sodium by Mixed Solvency Approach
Enhancement of solubility is one of the difficult tasks which become challenges in formulation development of orally administered drug with poor aqueous solubility. Poor water solubility of drugs often causes significant problems in producing formulations of sufficiently high bioavailability, preventing effective use of the drugs. 'Mixed-solvency ' concept is the phenomenon to increase the solu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pharmaceutics
سال: 2013
ISSN: 2090-9918,2090-7818
DOI: 10.1155/2013/678132